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5-Amino-1MQ Capsules

Price range: $100.00 through $175.00

This compound is studied in biochemical research for its interaction with nicotinamide N methyltransferase (NNMT) and related NAD⁺ metabolic pathways. Laboratory investigations focus on enzymatic regulation, methylation dynamics, and cellular energy signaling models.

Count
30 or 60 capsules
Per capsule
50 mg
Form
Capsules, sealed container
Purity
99%+
Storage
Cool, dry place · keep sealed
Intended use
Laboratory research only
Ships same day when you order by 2pm ESTFree UPS Ground over $175 · Free 2nd Day Air over $250

5-Amino-1MQ Capsules Research Overview

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule, membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is a cytosolic enzyme, highly expressed in adipose tissue and liver, that methylates nicotinamide using S-adenosylmethionine (SAM) to form 1-methylnicotinamide.

Because NNMT activity draws on both the nicotinamide and methyl-donor pools, 5-Amino-1MQ has been studied for its effects on intracellular NAD+ and SAM levels and on cellular energy metabolism. In diet-induced obese mouse models, it has been researched in connection with adipocyte size, lipogenesis, and body-weight changes, and NNMT inhibition has also been examined in aged-mouse models of skeletal muscle function.

Important Notice

5-Amino-1MQ Capsules is provided strictly for research use only. It is not intended for human or animal use, clinical purposes, diagnostic work, or consumption. Qualified professionals must conduct all research in proper laboratory environments and in compliance with applicable regulations and guidelines.

Product Form & Stability

This research compound is supplied in capsule form, with each capsule containing a pre-measured quantity of the compound.

The encapsulated format supports consistent handling, portioning, and storage within laboratory settings. Capsules are supplied ready for laboratory handling and do not require reconstitution.

No instructions regarding administration or use outside of laboratory research are provided.

Research Use Only

This product is intended exclusively for laboratory, analytical, and in-vitro research purposes.

It is not approved for human or veterinary use, diagnostic procedures, or therapeutic applications of any kind.

Handling and use should be performed only by qualified professionals within a controlled research environment.

Storage & Handling
  • Store in a cool, dry location, protected from light and moisture
  • Keep the container tightly closed when not in use
  • Proper storage conditions are the responsibility of the purchaser
Product Notes

Capsule products sold by Thrive Biolab LLC are shipped in sealed containers.

We are unable to provide guidance related to dosing, administration, or any use outside of research contexts.

Products are manufactured and supplied with a focus on purity, consistency, and documentation suitable for research applications.

Intended Use Disclaimer

All products offered on this website are provided solely for research and development purposes and are not for human or animal consumption.

Statements on this website have not been evaluated by the U.S. Food and Drug Administration (FDA). These products are not intended to diagnose, treat, cure, or prevent any disease.

Company Disclosure

Thrive Biolab LLC operates as a research chemical supplier.

We are not a compounding pharmacy under Section 503A of the Federal Food, Drug, and Cosmetic Act, nor are we an outsourcing facility under Section 503B of the Act.

All products are sold strictly for laboratory, analytical, and research use only.

The peer-reviewed publications below are indexed on PubMed and provided for scientific reference only. Their inclusion does not suggest that this product is intended for any use described in them. All products are sold strictly for laboratory research use.

5-Amino-1MQ & NNMT inhibition

  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceBiochem Pharmacol, 2018 · PMID 29155147
  2. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesityNature, 2014 · PMID 24717514
  3. Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged miceSci Rep, 2024 · PMID 38969654
  4. Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studiesJ Pharm Biomed Anal, 2021 · PMID 34304009